Most neurodegenerative diseases are characterized by the deposition of misfolded proteins (e.g., -synuclein, -amyloid, huntingtin) and degeneration of brain networks (Vaquer-Alicea and Diamond 2019)
Skeletal demineralization and fractures caused by fetal magnesium toxicity
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Injectable routes carry a particular concern for immunogenicity from peptide aggregation and impurities, and FDA noted the available certificates of analysis for AOD-9604 bulk drug substances did not consistently control for impurities, aggregates, or microbial limits
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"BPC-157 accelerated tendon-to-bone repair in a rat model via fibroblast proliferation and collagen synthesis." Staresinic et al., J
